Reflective liquid crystal hybrid beam-steerer

We report on efficient optical beam-steering using a hot-embossed reflective blazed grating in combination with liquid crystal. A numerical simulation of the electrical switching characteristics of the liquid crystal is performed and the results are used in an FDTD optical simulator to analyze the beam deflection. The corresponding experiment on the realized device is performed and is found to be in good agreement. Beam deflection angles of 4.4° upon perpendicular incidence are found with low applied voltages of 3.4V. By tilting the device with respect to the incoming optical beam it can be electronically switched such that the beam undergoes either total internal reflection or reflection with a tunable angle

Calcium puffs are generic InsP₃-activated elementary calcium signals and are downregulated by prolonged hormonal stimulation to inhibit cellular calcium responses

Elementary Ca2+ signals, such as "Ca2+ puffs", which arise from the activation of inositol 1,4,5-trisphosphate receptors, are building blocks for local and global Ca2+ signalling. We characterized Ca2+ puffs in six cell types that expressed differing ratios of the three inositol 1,4,5-trisphosphate receptor isoforms. The amplitudes, spatial spreads and kinetics of the events were similar in each of the cell types. The resemblance of Ca2+ puffs in these cell types suggests that they are a generic elementary Ca2+ signal and, furthermore, that the different inositol 1,4,5-trisphosphate isoforms are functionally redundant at the level of subcellular Ca2+ signalling. Hormonal stimulation of SH-SY5Y neuroblastoma cells and HeLa cells for several hours downregulated inositol 1,4,5-trisphosphate expression and concomitantly altered the properties of the Ca2+ puffs. The amplitude and duration of Ca2+ puffs were substantially reduced. In addition, the number of Ca2+ puff sites active during the onset of a Ca2+ wave declined. The consequence of the changes in Ca2+ puff properties was that cells displayed a lower propensity to trigger regenerative Ca2+ waves. Therefore, Ca2+ puffs underlie inositol 1,4,5-trisphosphate signalling in diverse cell types and are focal points for regulation of cellular responses

Active optical beam shaping based on liquid crystals and polymer micro-structures

Emerging applications requiring light beam manipulation, such as high-efficiency sunlight concentrators for solar cells, switchable micro-lens arrays for autostereoscopic displays, tunable lenses for augmented reality goggles, auto-focusing spectacles, and smart contact lenses, mostly depend on one or more active optical components with the desired and controllable beam modifying functionalities, preferably manufactured at relatively low cost. Recent progress in research on components based on the combination of liquid crystals (LCs) and various polymer micro-structures is reviewed in this paper. It is found that such components can address the demands appropriately and have the potential of paving the way for large-scale applications of active optical beam shaping components

Heterogeneous antimicrobial activity in broncho-alveolar aspirates from mechanically ventilated intensive care unit patients

Pneumonia is an infection of the lungs, where the alveoli in the affected area are filled with pus and fluid. Although ventilated patients are at risk, not all ventilated patients develop pneumonia. This suggests that the sputum environment may possess antimicrobial activities. Despite the generally acknowledged importance of antimicrobial activity in protecting the human lung against infections, this has not been systematically assessed to date. Therefore, the objective of the present study was to measure antimicrobial activity in broncho-alveolar aspirate ('sputum") samples from patients in an intensive care unit (ICU) and to correlate the detected antimicrobial activity with antibiotic levels, the sputum microbiome, and the respective patients' characteristics. To this end, clinical metadata and sputum were collected from 53 mechanically ventilated ICU patients. The antimicrobial activity of sputum samples was tested against Streptococcus pneumoniae, Staphylococcus aureus and Streptococcus anginosus. Here we show that sputa collected from different patients presented a high degree of variation in antimicrobial activity, which can be partially attributed to antibiotic therapy. The sputum microbiome, although potentially capable of producing antimicrobial agents, seemed to contribute in a minor way, if any, to the antimicrobial activity of sputum. Remarkably, despite its potentially protective effect, the level of antimicrobial activity in the investigated sputa correlated inversely with patient outcome, most likely because disease severity outweighed the beneficial antimicrobial activities.</p

Superstring field theory equivalence: Ramond sector

We prove that the finite gauge transformation of the Ramond sector of the modified cubic superstring field theory is ill-defined due to collisions of picture changing operators. Despite this problem we study to what extent could a bijective classical correspondence between this theory and the (presumably consistent) non-polynomial theory exist. We find that the classical equivalence between these two theories can almost be extended to the Ramond sector: We construct mappings between the string fields (NS and Ramond, including Chan-Paton factors and the various GSO sectors) of the two theories that send solutions to solutions in a way that respects the linearized gauge symmetries in both sides and keeps the action of the solutions invariant. The perturbative spectrum around equivalent solutions is also isomorphic. The problem with the cubic theory implies that the correspondence of the linearized gauge symmetries cannot be extended to a correspondence of the finite gauge symmetries. Hence, our equivalence is only formal, since it relates a consistent theory to an inconsistent one. Nonetheless, we believe that the fact that the equivalence formally works suggests that a consistent modification of the cubic theory exists. We construct a theory that can be considered as a first step towards a consistent RNS cubic theory.Comment: v1: 24 pages. v2: 27 pages, significant modifications of the presentation, new section, typos corrected, references adde

Analytical Solutions of Open String Field Theory

In this work we review Schnabl's construction of the tachyon vacuum solution to bosonic covariant open string field theory and the results that followed. We survey the state of the art of string field theory research preceding this construction focusing on Sen's conjectures and the results obtained using level truncation methods. The tachyon vacuum solution can be described in various ways. We describe its geometric representation using wedge states, its formal algebraic representation as a pure-gauge solution and its oscillator representation. We also describe the analytical proofs of some of Sen's conjectures for this solution. The tools used in the context of the vacuum solution can be adapted to the construction of other solutions, namely various marginal deformations. We present some of the approaches used in the construction of these solutions. The generalization of these ideas to open superstring field theory is explained in detail. We start from the exposition of the problems one faces in the construction of superstring field theory. We then present the cubic and the non-polynomial versions of superstring field theory and discuss a proposal suggesting their classical equivalence. Finally, the bosonic solutions are generalized to this case. In particular, we focus on the (somewhat surprising) generalization of the tachyon solution to the case of a theory with no tachyons.Comment: Invited review for Physics Reports. v1: 106 p., 8 fig. v2: 108 p., minor changes. v3: 117 p., 9 fig., presentation modified and expanded in several places, typos corrected, ref. added and updated. v4: Published version. 125 p., 10 fig., further modifications of the presentation, ref. added and update

High-Frequency (>100 GHz) and High-Speed (<1 ps) Electronic Devices

Contains an introduction, reports on three research projects and a list of publications.Advanced Research Projects Agency Contract MDA972-90-C-0021National Aeronautics and Space Administration Grant NAG2-693National Aeronautics and Space Administration Contract 959705National Science Foundation/MRSEC Grant DMR 94-00334MIT Lincoln Laboratory Advanced Concept Program Contract BX-5464MIT Research Laboratory of Electronics Postdoctoral FellowshipRome Air Force Laboratory Graduate FellowshipU.S. Army Research Office Grant DAAL03-92-G-0251Hertz Foundation FellowshipU.S. Army Research Office/ASSERT Grant DAAH04-94-G-016